▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Studies performed over the past five years have demonstrated that there are two major cell-
intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death …

Mitochondria play a key part in the regulation of apoptosis (cell death),. Their intermembrane
space contains several proteins that are liberated through the outer membrane in order to …

The concept of apoptotic cell death as an essential part of the development and life of
complex organisms has been devised in different situations and tested from various angles …

Apaf-1−/− or caspase-3−/− cells treated with a variety of apoptosis inducers manifest
apoptosis-associated alterations including the translocation of apoptosis-inducing factor …

Inflammation is a disease of vigorous uncontrolled activated immune responses.
Overwhelming reports have suggested that the modulation of immune responses by …

Apoptosis is defined by several unique morphological nuclear changes, such as chromatin
condensation and nuclear fragmentation. These changes are triggered by the activation of a …

Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous
nucleases cleave DNA within the dying cell. They are not essential for apoptotic cell death or …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

Acute postasphyxial encephalopathy around the time of birth remains a major cause of
death and disability. The possibility that hypothermia may be able to prevent or lessen …