Galangin's potential as a functional food ingredient

KK Mak, JJ Tan, P Marappan, MK Balijepalli… - Journal of Functional …, 2018 - Elsevier
Foods that show positive effects on health beyond basic nutrition are called functional foods
of which familiar examples are propolis and Alpinia officinarum. Galangin (3, 4, 5 …

Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data

B Chen, X Dong, D Jiao, H Wang, Q Zhu, Y Ding… - BMC …, 2010 - Springer
Background Recently there has been an explosion of new data sources about genes,
proteins, genetic variations, chemical compounds, diseases and drugs. Integration of these …

Phytochemistry and bioactivity of Acacia sensu stricto (Fabaceae: Mimosoideae)

D Jaeger, MC O'Leary, P Weinstein, BL Møller… - Phytochemistry …, 2019 - Springer
Abstract Acacia sensu lato (Fabaceae: Mimosoideae) was recently retypified and divided
into five genera worldwide: Acacia, Acaciella, Mariosousa, Senegalia and Vachellia. Acacia …

Learning by extrapolation from marginal to full-multivariate probability distributions: decreasingly naive Bayesian classification

GI Webb, JR Boughton, F Zheng, KM Ting, H Salem - Machine learning, 2012 - Springer
Abstract Averaged n-Dependence Estimators (A n DE) is an approach to probabilistic
classification learning that learns by extrapolation from marginal to full-multivariate …

Identification of compounds selectively killing multidrug-resistant cancer cells

D Türk, MD Hall, BF Chu, JA Ludwig, HM Fales… - Cancer research, 2009 - AACR
There is a great need for the development of novel chemotherapeutic agents that overcome
the emergence of multidrug resistance (MDR) in cancer. We catalogued the National Cancer …

Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models

A Paul, R Anand, SP Karmakar, S Rawat, N Bairagi… - Scientific reports, 2021 - nature.com
Research on new cancer drugs is performed either through gene knockout studies or
phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and …

Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

D Slade, AM Galal, W Gul, MM Radwan… - Bioorganic & medicinal …, 2009 - Elsevier
Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were
synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity …

A membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent

X Yao, NH Watkins, H Brown-Harding, U Bierbach - Scientific Reports, 2020 - nature.com
Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive
components of personalized combination regimens for combatting aggressive forms of …

Noncovalent binding to DNA: still a target in developing anticancer agents

J Portugal, F Barcelo - Current Medicinal Chemistry, 2016 - ingentaconnect.com
DNA-binding compounds are of extraordinary importance in medicine, accounting for a
substantial portion of antitumor drugs in clinical usage. However, their mechanisms of action …

Classification and virtual screening of androgen receptor antagonists

J Li, P Gramatica - Journal of chemical information and modeling, 2010 - ACS Publications
Computational tools, such as quantitative structure− activity relationship (QSAR), are highly
useful as screening support for prioritization of substances of very high concern (SVHC) …