Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Most cancer vaccines target peptide antigens, necessitating personalization owing to the
vast inter-individual diversity in major histocompatibility complex (MHC) molecules that …

Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8+
T cells, and subsets of CD4+ T cells, invariant NKT cells (iNKT), and γδ T cells. In humans …

Background & Aims No adjuvant therapy has been shown to extend the survival of patients
with hepatocellular carcinoma (HCC) receiving curative treatment. We investigated whether …

The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

Several immunotherapy approaches that mobilize CD8+ T cell responses stimulate tumor
rejection, and some, such as checkpoint blockade, have been approved for several cancer …

Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …