Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Cell penetrating peptides hold considerable potential for academic and pharmaceutical
remits with an interest in delivering macromolecules to the insides of cells. Hundreds of …

Screening of phage libraries expressing random peptides for binding to prostate cancer
cells primarily yielded peptides that had a C-terminal arginine (or rarely lysine) residue …

We have devised and tested a new strategy for selectively delivering molecules to tumor
cells. Cellular association of polyarginine-based, cell-penetrating peptides (CPPs) is …

In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

• Introduction• Membrane ruffling and the formation of the macropinosome• Rabs and
macropinocytosis• The fate of the macropinosome on the endocytic pathway• A role for …

Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a
growing number of biological applications have been explored. To be effective, these …

Cell-penetrating peptides (CPPs) traverse the membrane of biological cells at low
micromolar concentrations and are able to take various cargo molecules along with. Despite …

Delineating the mechanisms by which cell-penetrating peptides, such as HIV-Tat peptide,
oligoarginines and penetratin, gain access to cells has recently received intense scrutiny …