The immune nature of platelets revisited

A Maouia, J Rebetz, R Kapur, JW Semple - Transfusion medicine reviews, 2020 - Elsevier
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Exploring multivalent carbohydrate–protein interactions by NMR

JI Quintana, U Atxabal, L Unione, A Ardá… - Chemical Society …, 2023 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …

Molecular recognition in C‐type lectins: the cases of DC‐SIGN, Langerin, MGL, and L‐sectin

P Valverde, JD Martinez, FJ Cañada, A Arda… - …, 2020 - Wiley Online Library
Carbohydrates play a pivotal role in intercellular communication processes. In particular,
glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish …

Fluorinated Man9 as a High Mannose Mimetic to Unravel Its Recognition by DC-SIGN Using NMR

A Silva-Díaz, J Ramírez-Cárdenas… - Journal of the …, 2023 - ACS Publications
Lectins are capable of reading out the structural information contained in carbohydrates
through specific recognition processes. Determining the binding epitope of the sugar is …

Rational-differential design of highly specific glycomimetic ligands: targeting DC-SIGN and excluding langerin recognition

V Porkolab, E Chabrol, N Varga, S Ordanini… - ACS chemical …, 2017 - ACS Publications
At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of
carbohydrate-based PAMPS or DAMPS (pathogen-or danger-associated molecular …

Molecular insights into DC-SIGN binding to self-antigens: The interaction with the blood group A/B antigens

P Valverde, S Delgado, JD Martínez… - ACS chemical …, 2019 - ACS Publications
The dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-
SIGN) is an important receptor of the immune system. Besides its role as pathogen …

Examining binding to nanoparticle surfaces using saturation transfer difference (STD)-NMR spectroscopy

Y Zhang, H Xu, AM Parsons… - The Journal of Physical …, 2017 - ACS Publications
The interaction of molecules with the surface of nanoparticles is important in many fields of
study, including drug delivery and nanoparticle toxicity. Solution-state NMR has the potential …

Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes

F Nieto-Fabregat, Q Zhu, C Vivès, Y Zhang… - JACS Au, 2024 - ACS Publications
The evaluation of Bacteroides vulgatus mpk (BVMPK) lipopolysaccharide (LPS) recognition
by DC-SIGN, a key lectin in mediating immune homeostasis, has been here performed. A …

Molecular recognition of Escherichia coli R1-type core lipooligosaccharide by DC-SIGN

F Nieto-Fabregat, A Marseglia, M Thépaut, JP Kleman… - Iscience, 2024 - cell.com
Due to their ability to recognize carbohydrate structures, lectins emerged as potential
receptors for bacterial lipopolysaccharides (LPS). Despite growing interest in investigating …

Polyvalent C-glycomimetics based on L-fucose or D-mannose as potent DC-SIGN antagonists

B Bertolotti, I Sutkeviciute, M Ambrosini… - Organic & …, 2017 - pubs.rsc.org
The C-type lectin DC-SIGN expressed on immature dendritic cells is a promising target for
antiviral drug development. Previously, we have demonstrated that mono-and divalent C …