CYP2B6 functional variability in drug metabolism and exposure across populations—implication for drug safety, dosing, and individualized therapy
IM Langmia, KS Just, S Yamoune, J Brockmöller… - Frontiers in …, 2021 - frontiersin.org
Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …
Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …
Integration of antiretroviral therapy with tuberculosis treatment
SS Abdool Karim, K Naidoo, A Grobler… - … England Journal of …, 2011 - Mass Medical Soc
Background We previously reported that integrating antiretroviral therapy (ART) with
tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during …
tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during …
Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: results of a phase 1 …
KE Dooley, P Sayre, J Borland, E Purdy… - JAIDS Journal of …, 2013 - journals.lww.com
Background: Cotreatment of tuberculosis (TB) and HIV among coinfected patients is now the
standard of care. Rifampin (RIF) is a standard part of TB treatment but is a potent inducer of …
standard of care. Rifampin (RIF) is a standard part of TB treatment but is a potent inducer of …
Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients
G Yimer, N Ueda, A Habtewold, W Amogne, A Suda… - PLoS …, 2011 - journals.plos.org
Background Implication of pharmacogenetic variations and efavirenz pharmacokinetics in
concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury …
concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury …
Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a …
JK Mukonzo, A Okwera, N Nakasujja, H Luzze… - BMC infectious …, 2013 - Springer
Background HIV infection, anti-tuberculosis and efavirenz therapy are associated with
neuropsychological effects. We evaluated the influence of rifampicin cotreatment, efavirenz …
neuropsychological effects. We evaluated the influence of rifampicin cotreatment, efavirenz …
Pharmacogenetics of plasma efavirenz exposure in HIV‐infected adults and children in South Africa
PZ Sinxadi, PD Leger, HM McIlleron… - British journal of …, 2015 - Wiley Online Library
Aims Genetic factors, notably CYP2B6 516G→ T [rs3745274] and 983T→ C [rs28399499],
explain much of the interindividual variability in efavirenz pharmacokinetics, but data from …
explain much of the interindividual variability in efavirenz pharmacokinetics, but data from …
Management of individuals requiring antiretroviral therapy and TB treatment
K Cohen, G Meintjes - Current Opinion in HIV and AIDS, 2010 - journals.lww.com
ART improves survival in co-infected TB patients, but is complicated by several management
challenges that compromise programmatic implementation in resource-limited settings …
challenges that compromise programmatic implementation in resource-limited settings …
Treatment Optimization in Patients Co-Infected with HIV and Mycobacterium tuberculosis Infections: Focus on Drug–Drug Interactions with Rifamycins
M Regazzi, AC Carvalho, P Villani, A Matteelli - Clinical pharmacokinetics, 2014 - Springer
Tuberculosis (TB) and HIV continue to be two of the major causes of morbidity and mortality
in the world, and together are responsible for the death of millions of people every year …
in the world, and together are responsible for the death of millions of people every year …
Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review
The HIV-associated tuberculosis (TB) epidemic remains a huge challenge to public health in
resource-limited settings. Reducing the nearly 0.5 million deaths that result each year has …
resource-limited settings. Reducing the nearly 0.5 million deaths that result each year has …