Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure

VB Patel, JC Zhong, MB Grant, GY Oudit - Circulation research, 2016 - Am Heart Assoc
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19

D Zipeto, JF Palmeira, GA Argañaraz… - Frontiers in …, 2020 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …

Neutrophils and neutrophil extracellular traps drive necroinflammation in COVID-19

B Tomar, HJ Anders, J Desai, SR Mulay - Cells, 2020 - mdpi.com
The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an
urgent need for novel therapeutic strategies to combat potentially fatal complications …

Diabetes and COVID-19: evidence, current status and unanswered research questions

R Gupta, A Hussain, A Misra - European journal of clinical nutrition, 2020 - nature.com
Patients with diabetes who get coronavirus disease 2019 (COVID-19) are at risk of a severe
disease course and mortality. Several factors especially the impaired immune response …

The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research

TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

Should anti-diabetic medications be reconsidered amid COVID-19 pandemic?

R Pal, SK Bhadada - Diabetes …, 2020 - diabetesresearchclinicalpractice …
Ever since its outbreak in December 2019, the novel coronavirus disease (COVID-19),
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to …

Therapeutic potential of metformin in COVID-19: reasoning for its protective role

SM Samuel, E Varghese, D Büsselberg - Trends in microbiology, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with
increased disease severity and poor clinical outcomes in diabetic patients compared with …

Covid-19 and diabetes: a complex bidirectional relationship

H Muniangi-Muhitu, E Akalestou, V Salem… - Frontiers in …, 2020 - frontiersin.org
Covid-19 is a recently-emerged infectious disease caused by the novel severe acute
respiratory syndrome coronavirus SARS-CoV2. SARS-CoV2 differs from previous …

Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing

E Varghese, SM Samuel, A Liskova, P Kubatka… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a …

Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension

J Xu, S Sriramula, H Xia, L Moreno-Walton… - Circulation …, 2017 - Am Heart Assoc
Rationale: Neurogenic hypertension is characterized by an increase in sympathetic activity
and often resistance to drug treatments. We previously reported that it is also associated with …