Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

We survey the evidence for L-glutamate's role as the primary excitatory neurotransmitter of
vertebrate retinas. The physiological and molecular properties of glutamate receptors in the …

The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2)
maps to a 1.1-Mb region in Xp11. 23 between markers DXS722 and DXS255. We identified …

We investigated the impact of rod-bipolar signal transfer on visual sensitivity. Two
observations indicate that rod-rod bipolar signal transfer is nonlinear. First, responses of …

The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is
reviewed in relation to the process of neurotransmitter release. The interactions between …

▪ Abstract The past decade has witnessed extraordinary progress in retinal disease gene
identification, the analysis of animal and tissue culture models of disease processes, and the …

▪ Abstract Vision at absolute threshold is based on signals produced in a tiny fraction of the
rod photoreceptors. This requires that the rods signal the absorption of single photons, and …

Voltage-gated Ca 2+ channels couple membrane depolarization to Ca 2+-dependent
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …

In this review we describe some of the remarkable and intricate mechanisms through which
the calcium ion (Ca 2+) contributes to detection, transduction and synaptic transfer of light …

Studies of the properties of synaptic transmission have been carried out at only a few
synapses. We analyzed exocytosis from rod photoreceptors with a combination of …