Towards fully integrated liquid chromatography on a chip: evolution and evaluation

F Haghighi, Z Talebpour, AS Nezhad - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
Miniaturization of liquid chromatography (LC) is at the leading edge of the research topics
and offers a wide range of applications in chemistry, biology, pharmaceutical, clinical …

Advancements in automation for plasma proteomics sample preparation

CD King, KL Kapp, AB Arul, MJ Choi… - Molecular omics, 2022 - pubs.rsc.org
Automation is necessary to increase sample processing throughput for large-scale clinical
analyses. Replacement of manual pipettes with robotic liquid handler systems is especially …

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

A Cvetko, M Mangino, M Tijardović, D Kifer… - BMJ open diabetes …, 2021 - drc.bmj.com
Introduction Prediction of type 2 diabetes mellitus (T2DM) and its preceding factors, such as
insulin resistance (IR), is of great importance as it may allow delay or prevention of onset of …

Perspectives on the optimal genetically engineered pig in 2018 for initial clinical trials of kidney or heart xenotransplantation

DKC Cooper, M Ezzelarab, H Iwase, H Hara - Transplantation, 2018 - journals.lww.com
For a clinical trial today, what might realistically be the optimal pig among those currently
available? Deletion of expression of the 3 pig carbohydrate antigens, against which humans …

Janus face of complement-driven neutrophil activation during sepsis

R Halbgebauer, CQ Schmidt, CM Karsten… - Seminars in …, 2018 - Elsevier
During local and systemic inflammation, the complement system and neutrophil
granulocytes are activated not only by pathogens, but also by released endogenous danger …

Label-free plasma proteomics identifies haptoglobin-related protein as candidate marker of idiopathic pulmonary fibrosis and dysregulation of complement and …

M Saraswat, S Joenväärä, T Tohmola, E Sutinen… - Scientific Reports, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a lung parenchymal disease of unknown cause usually
occurring in older adults. It is a chronic and progressive condition with poor prognosis and …

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients

M Serrano-Maciá, S Lachiondo-Ortega… - Cell Death …, 2022 - nature.com
The COVID-19 pandemic caused by SARS-CoV-2 has reached 5.5 million deaths
worldwide, generating a huge impact globally. This highly contagious viral infection …

Quantitative N-glycoproteomics reveals altered glycosylation levels of various plasma proteins in bloodstream infected patients

S Joenvaara, M Saraswat, P Kuusela, S Saraswat… - PloS one, 2018 - journals.plos.org
Bloodstream infections are associated with high morbidity and mortality with rates varying
from 10–25% and higher. Appropriate and timely onset of antibiotic therapy influences the …

Comparing serum protein levels can aid in differentiating HPV-negative and-positive oropharyngeal squamous cell carcinoma patients

A Dickinson, M Saraswat, S Syrjänen, T Tohmola… - PLoS …, 2020 - journals.plos.org
Background The surrogate immunohistochemical marker, p16INK4a, is used in clinical
practice to determine the high-risk human papillomavirus (HPV) status of oropharyngeal …

Weathered polyethylene microplastics induced immunomodulation in zebrafish

T Harikrishnan, P Paramasivam, A Sankar… - Environmental …, 2024 - Elsevier
Microplastics are pollutants of emerging concern and the aquatic biota consumes
microplastics (MPs), which has a range of toxicological and environmental effects on aquatic …