The pain of social disconnection: examining the shared neural underpinnings of physical and social pain

NI Eisenberger - Nature reviews neuroscience, 2012 - nature.com
Experiences of social rejection, exclusion or loss are generally considered to be some of the
most'painful'experiences that we endure. Indeed, many of us go to great lengths to avoid …

Animal models of nociception

D Le Bars, M Gozariu, SW Cadden - Pharmacological reviews, 2001 - ASPET
The study of pain in awake animals raises ethical, philosophical, and technical problems.
We review the ethical standards for studying pain in animals and emphasize that there are …

Fear and anxiety: divergent effects on human pain thresholds

JL Rhudy, MW Meagher - Pain, 2000 - Elsevier
Animal studies suggest that fear inhibits pain whereas anxiety enhances it; however it is
unclear whether these effects generalize to humans. The present study examined the effects …

Exacerbation of pain by anxiety is associated with activity in a hippocampal network

A Ploghaus, C Narain, CF Beckmann… - Journal of …, 2001 - Soc Neuroscience
It is common clinical experience that anxiety about pain can exacerbate the pain sensation.
Using event-related functional magnetic resonance imaging (FMRI), we compared activation …

Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder

V Rau, JP DeCola, MS Fanselow - Neuroscience & biobehavioral reviews, 2005 - Elsevier
Fear is an adaptive response that initiates defensive behavior to protect animals and
humans from danger. However, anxiety disorders, such as Posttraumatic Stress Disorder …

Affective modulation of nociception at spinal and supraspinal levels

JL Rhudy, AE Williams, KM McCabe… - …, 2005 - Wiley Online Library
This study was designed to examine the effect of emotion on the nociceptive flexion reflex
and pain ratings. To do so, 28 participants viewed pictures varying in emotional valence …

Dopaminergic modulation of risky decision-making

NW Simon, KS Montgomery, BS Beas… - Journal of …, 2011 - Soc Neuroscience
Many psychiatric disorders are characterized by abnormal risky decision-making and
dysregulated dopamine receptor expression. The current study was designed to determine …

The role of emotion in pain modulation

JL Rhudy, MW Meagher - Current Opinion in Psychiatry, 2001 - journals.lww.com
Although most agree that emotion can alter pain, little well-controlled research has been
conducted to examine this issue. The present review provides psychological and …

Gender differences in pain: do emotions play a role?

JL Rhudy, AE Williams - Gender medicine, 2005 - Elsevier
BACKGROUND:: Research suggests that the influence of gender on the processing and
experience of pain is a result of several mechanisms. One mediating variable is emotion …

Negative affect: effects on an evaluative measure of human pain

JL Rhudy, MW Meagher - Pain, 2003 - Elsevier
Prior work indicates that exposure to fear-inducing shock inhibits finger-withdrawal to radiant
heat in humans (hypoalgesia), whereas anxiety induced by threat of shock enhances …