The peptide substance P (SP) shows a widespread distribution in both the central and
peripheral nervous systems, but it is also present in cells not belonging to the nervous …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

RNA interference (RNAi) technology has been used for almost two decades to study gene
functions and in therapeutic approaches. It uses cellular machinery and small, designed …

Sponsored by the New York Academy of Sciences, the Warren Alpert Medical School of
Brown University and the University of Massachusetts Boston,“Behavioral Epigenetics” was …

Immune or brain proinflammatory signaling has been linked to some of the behavioral
effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent …

Acute alcohol intoxication causes cellular changes in the brain that last for hours, while
chronic alcohol use induces widespread neuroadaptations in the nervous system that can …

Addictive disorders are chronic, relapsing conditions that cause extensive disease burden.
Genetic factors partly account for susceptibility to addiction, but environmental factors such …

Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that
preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and …

Alcohol addiction is a major social and health concern. Here, we determined the expression
profile of microRNAs (miRNAs) in the nucleus accumbens (NAc) of rats treated with alcohol …

Prolonged drug use causes long-lasting neuroadaptations in reward-related brain areas that
contribute to addiction. Despite significant amount of research dedicated to understanding …