Integrating biological imaging into early stages of the drug discovery process can provide
invaluable readouts of drug activity within complex disease settings, such as cancer …

Introduction: Fluorescence anisotropy (FA) is one of the major established methods
accepted by industry and regulatory agencies for understanding the mechanisms of drug …

Protein N-myristoylation is a ubiquitous co-and post-translational modification that has been
implicated in the development and progression of a range of human diseases. Here, we …

Fluorescence lifetime imaging (FLIM) is widely applied to obtain quantitative information
from fluorescence signals, particularly using Förster Resonant Energy Transfer (FRET) …

We present a high content multiwell plate cell-based assay approach to quantify protein
interactions directly in cells using Förster resonance energy transfer (FRET) read out by …

The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase
transition, mitosis and the DNA damage response. As such, it is frequently deregulated …

Optical imaging assays, especially fluorescence molecular assays, are minimally invasive if
not completely noninvasive, and thus an ideal technique to be applied to live specimens …

In this review, we discuss methods and advancements in fluorescence lifetime imaging
microscopy that permit measurements to be performed at faster speed and higher resolution …

The nematode worm Caenorhabditis elegans has emerged as an important model organism
in the study of the molecular mechanisms of protein misfolding diseases associated with …

Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that
has been proposed to be a selective autophagy receptor for glycogen. Here, we show that …