Metabolomics activity screening for identifying metabolites that modulate phenotype
Metabolomics, in which small-molecule metabolites (the metabolome) are identified and
quantified, is broadly acknowledged to be the omics discipline that is closest to the …
quantified, is broadly acknowledged to be the omics discipline that is closest to the …
Metabolite measurement: pitfalls to avoid and practices to follow
Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …
influenced by an individual's genetics and the composition of their diet and gut microbiome …
Bioaccumulation of therapeutic drugs by human gut bacteria
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic mapping of the interactions between drugs and bacteria has only started …
the systematic mapping of the interactions between drugs and bacteria has only started …
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community
Microbial communities often undergo intricate compositional changes yet also maintain
stable coexistence of diverse species. The mechanisms underlying long-term coexistence …
stable coexistence of diverse species. The mechanisms underlying long-term coexistence …
[HTML][HTML] The long-term genetic stability and individual specificity of the human gut microbiome
By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183
metabolites in 338 individuals after 4 years, we characterize microbial stability and variation …
metabolites in 338 individuals after 4 years, we characterize microbial stability and variation …
[HTML][HTML] Modulation of myelopoiesis progenitors is an integral component of trained immunity
I Mitroulis, K Ruppova, B Wang, LS Chen, M Grzybek… - Cell, 2018 - cell.com
Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass
spectrometry, we generated dynamic metabolome and proteome profiles of human primary …
spectrometry, we generated dynamic metabolome and proteome profiles of human primary …
The maternal microbiota drives early postnatal innate immune development
M Gomez de Agüero, SC Ganal-Vonarburg, T Fuhrer… - Science, 2016 - science.org
Postnatal colonization of the body with microbes is assumed to be the main stimulus to
postnatal immune development. By transiently colonizing pregnant female mice, we show …
postnatal immune development. By transiently colonizing pregnant female mice, we show …