RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
A Penn-Nicholson, SK Mbandi, E Thompson… - Scientific reports, 2020 - nature.com
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …
Does PET-CT have a role in the evaluation of tuberculosis treatment in phase 2 clinical trials?
GB Cross, J O'Doherty, CC Chang… - The Journal of …, 2024 - academic.oup.com
Positron emission tomography–computed tomography (PET-CT) has the potential to
revolutionize research in infectious diseases, as it has done with cancer. There is growing …
revolutionize research in infectious diseases, as it has done with cancer. There is growing …
Advances in the diagnosis and treatment of latent tuberculosis infection
YEG Jung, NW Schluger - Current opinion in infectious diseases, 2020 - journals.lww.com
Advances in the diagnosis and treatment of latent tuberculos... : Current Opinion in Infectious
Diseases Advances in the diagnosis and treatment of latent tuberculosis infection : Current …
Diseases Advances in the diagnosis and treatment of latent tuberculosis infection : Current …
Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response
Background There is a growing interest in the use of F-18 FDG PET-CT to monitor
tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and …
tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and …
PET-CT outcomes from a randomised controlled trial of rosuvastatin as an adjunct to standard tuberculosis treatment
GB Cross, IP Sari, SM Burkill, CW Yap… - Nature …, 2024 - nature.com
Adjunctive rosuvastatin for rifampicin-susceptible pulmonary tuberculosis (rs-PTB) shows no
effect on microbiological or radiological outcomes in a phase IIb randomised, controlled trial …
effect on microbiological or radiological outcomes in a phase IIb randomised, controlled trial …
Investigating non-sterilizing cure in TB patients at the end of successful anti-TB therapy
Mycobacterium tuberculosis (Mtb) is extremely recalcitrant to antimicrobial chemotherapy
requiring 6 months to treat drug-sensitive tuberculosis (TB). Despite this, 4–10% of cured …
requiring 6 months to treat drug-sensitive tuberculosis (TB). Despite this, 4–10% of cured …
Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
Mycobacterium tuberculosis (M. tb) causes tuberculosis (TB) and remains one of the leading
causes of mortality due to an infectious pathogen. Host immune responses have been …
causes of mortality due to an infectious pathogen. Host immune responses have been …
Comparing gene expression profiles of adults with isolated spinal tuberculosis to disseminated spinal tuberculosis identified by 18FDG-PET/CT at time of diagnosis, 6 …
Background Tuberculosis (TB) is one of the top ten causes of death worldwide, with
approximately 10 million cases annually. Focus has been on pulmonary TB, while …
approximately 10 million cases annually. Focus has been on pulmonary TB, while …
The peripheral blood transcriptome is correlated with PET measures of lung inflammation during successful tuberculosis treatment
Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue
destruction. Here we used within-subject peripheral blood gene expression over time to …
destruction. Here we used within-subject peripheral blood gene expression over time to …
Risk Factors of Tuberculosis Destroyed Lung in Patients with Pulmonary Tuberculosis and Structural Lung Diseases: A Retrospective Observational Study
L Liu, X Wang, L Luo, X Liu, J Chen - Risk Management and …, 2024 - Taylor & Francis
Background Tuberculosis destroyed lung constitutes a significant worldwide public health
challenge, little is known about its associated risk factors and prognosis. Our study aimed to …
challenge, little is known about its associated risk factors and prognosis. Our study aimed to …