Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …

Although genetic association studies have been with us for many years, even for the
simplest analyses there is little consensus on the most appropriate statistical procedures …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …

The nature and scale of recombination rate variation are largely unknown for most species.
In humans, pedigree analysis has documented variation at the chromosomal level, and …

Our basic question is: Given a collection of DNA sequences, what underlying forces are
responsible for the observed patterns of variability? To approach this question we introduce …

Genome-wide association studies with SNP markers are expected to allow identification of
genes that underlie complex disorders. Hundreds of thousands of SNP markers will be …

Advances in genotyping and sequencing technologies, coupled with the development of
sophisticated statistical methods, have afforded investigators novel opportunities to define …

Dog domestication has probably started very early during the Upper paleolithic period (∼
35,000 BP), thus well before any other animal or plant domestication. This early process …

The 156 breeds of registered dogs in the United States offer a unique opportunity to map
genes important in disease susceptibility, morphology, and behavior. Linkage disequilibrium …