Objectives: An overview of biochemical markers of bone metabolism is presented along with
indications for their clinical utilization. Design and Methods: The structure, cyclical …

Background Osteoporosis is an abnormal reduction in bone mass and bone deterioration
leading to increased fracture risk. Alendronate belongs to the bisphosphonate class of …

Osteoporosis affects an estimated 75 million people in Europe, the United States, and
Japan. 1 It is a preventable and treatable condition, yet many people with osteoporosis …

Recent evidence has linked long-term bisphosphonate use with insufficiency fractures of the
femur in postmenopausal women. In this case–control study, we have identified a significant …

Treatment effects on bone quality and remodeling was assessed in postmenopausal women
with osteoporosis treated with oral alendronate. One transiliac bone biopsy was obtained …

Objective: To review the effect of alendronate on bone density and fractures in
postmenopausal women. Data Source: We searched MEDLINE, EMBASE, Current …

Geminal bisphosphonates (BPs) are a class of drugs considered to be stable analogs of
pyrophosphate (P–O–P), a physiological regulator of calcification and bone resorption. A …

BACKGROUND: The effects of the aminobisphosphonate alendronate sodium on bone
mass and markers of bone remodeling were investigated. PAnEms AND hWtioDs: In a …

The bisphosphonates (BPs) have been useful tools in our understanding of the role that
bone remodeling plays in skeletal health. The purpose of this paper is to outline what we …

Evidence is presented which supports the conclusion that the hormetic dose–response
model is the most common and fundamental in the biological and biomedical sciences …