[HTML][HTML] Alleviating anxiety and taming trauma: novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder
Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …
[HTML][HTML] Are fear and anxiety truly distinct?
L Daniel-Watanabe, PC Fletcher - Biological psychiatry global open science, 2022 - Elsevier
Fear and anxiety are largely seen as separate entities, a distinction that inspires and shapes
basic and clinical research. Evidence for this distinction has a rich translational base and …
basic and clinical research. Evidence for this distinction has a rich translational base and …
[HTML][HTML] Pathophysiology of nAChRs: limbic circuits and related disorders
Human epidemiological studies have identified links between nicotine intake and stress
disorders, including anxiety, depression and PTSD. Here we review the clinical evidence for …
disorders, including anxiety, depression and PTSD. Here we review the clinical evidence for …
Antidepressant-like properties of intrastriatal botulinum neurotoxin-a injection in a unilateral 6-ohda rat model of parkinson's disease
V Antipova, C Holzmann, A Hawlitschka, M Witt… - Toxins, 2021 - mdpi.com
Parkinson's patients often suffer from depression and anxiety, for which there are no optimal
treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal …
treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal …
[HTML][HTML] BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic-and antidepressant-like effects in rodents
This work describes the characterization of BNC210 (6-[(2, 3-dihydro-1H-inden-2-yl) amino]-
1-ethyl-3-(4-morpholinylcarbonyl)-1, 8-naphthyridin-4 (1H)-one), a selective, small molecule …
1-ethyl-3-(4-morpholinylcarbonyl)-1, 8-naphthyridin-4 (1H)-one), a selective, small molecule …
BNC210: an investigational α7-nicotinic acetylcholine receptor modulator for the treatment of anxiety disorders
Introduction Anxiety disorders are common, disabling psychiatric conditions associated with
excessive worry, irritability, and physiological symptoms of stress. Following insufficient …
excessive worry, irritability, and physiological symptoms of stress. Following insufficient …
A Neuroanatomic and Pathophysiologic Framework for Novel Pharmacological Approaches to the Treatment of Post-traumatic Stress Disorder
MA Norred, ZD Zuschlag, MB Hamner - Drugs, 2024 - Springer
Post-traumatic stress disorder (PTSD) is a debilitating disorder inflicting high degrees of
symptomatic and socioeconomic burdens. The development of PTSD results from a cascade …
symptomatic and socioeconomic burdens. The development of PTSD results from a cascade …
Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult …
Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor
(α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences …
(α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences …
[PDF][PDF] Zachary A. Rodd1, 2*, H. Scott Swartzwelder3, R. Aaron Waeiss1, 2, Serhii O. Soloviov4, 5, Debomoy K. Lahiri1, 2, 6, 7, 8, Eric A. Engleman1, 2, William A …
Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor
(α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences …
(α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences …
GABA System in Anxiety Disorders: A Review of Current and Novel GABAergic Drugs
Y Cai, E Xu - Journal of Education, Humanities and Social Sciences, 2023 - drpress.org
This is an article for defying diverse of drugs in GABA system showing effect in treating
anxiety or not. In the passage, the authors discuss the effect and side effect of levetiracetam …
anxiety or not. In the passage, the authors discuss the effect and side effect of levetiracetam …