Emerging phagocytosis checkpoints in cancer immunotherapy
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations
JA Seidel, A Otsuka, K Kabashima - Frontiers in oncology, 2018 - frontiersin.org
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I/II CheckMate 358 trial
PURPOSE Nivolumab was assessed in patients with virus-associated tumors in the phase
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
Thinking outside the box: non-canonical targets in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice
High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-
specific immunity, which enhances tumor control both locally and distantly. Unfortunately …
specific immunity, which enhances tumor control both locally and distantly. Unfortunately …
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
M Linnerbauer, T Beyer, L Nirschl, D Farrenkopf… - Nature …, 2023 - nature.com
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central
nervous system (CNS). Current therapies mainly target inflammatory processes during acute …
nervous system (CNS). Current therapies mainly target inflammatory processes during acute …
[HTML][HTML] PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
CL Tan, JR Kuchroo, PT Sage, D Liang… - Journal of Experimental …, 2021 - rupress.org
Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T
cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less …
cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less …
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
Neuroinflammation and neurodegeneration may represent two poles of brain pathology.
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
Regulation of microglial activation in stroke
S Zhao, L Ma, Z Chu, H Xu, W Wu, F Liu - Acta Pharmacologica Sinica, 2017 - nature.com
When ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events,
including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis …
including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis …
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
Co-inhibitory receptors are important regulators of T-cell function that define the balance
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …