Epilepsy is one of the most common and disabling neurologic conditions, yet we have an
incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for …

Epileptogenesis is defined as the process of developing epilepsy—a disorder characterized
by recurrent seizures—following an initial insult. Seizure incidence during the human …

Seizures are common among critically ill children, but their relationship to outcome remains
unclear. We sought to quantify the relationship between electrographic seizure burden and …

In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies
have limited efficacy. Although the treatment of neonatal seizures has not significantly …

Intracranial hemorrhage (ICH) in the premature infant is an acquired lesion with enormous
potential impact on morbidity, mortality, and long-term neurodevelopmental outcome …

Neonatal seizures are an important example of an age-specific seizure syndrome.
Compared with seizures at older ages, neonatal seizures differ in etiology, semiology, and …

The highest incidence of seizures during lifetime is found in the neonatal period and
neonatal seizures lead to a propensity for epilepsy and long-term cognitive deficits. Here, we …

Importance Seizures in the neonatal period are associated with increased mortality and
morbidity. Bedside amplitude-integrated electroencephalography (aEEG) has facilitated the …

An imbalance between oxidants and antioxidants has been postulated to lead to oxidative
damage in traumatic brain injury (TBI). Oxidative neurodegeneration is a key mediator of …

Background We tested the hypothesis that in newborn rats, sevoflurane may cause seizures,
neurotoxicity, and impairment in synaptic plasticity-effects that may be diminished by the Na …