Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …

Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer
composed of mitotically quiescent cells. Tight junctions and adherens junctions maintain the …

Purpose To review the literature on the application of bioinformatics and artificial intelligence
(AI) for analysis of biofluid biomarkers in retinal vein occlusion (RVO) and their potential …

Multiple lines of evidence support an immunologic response along with inflammation to be
implicated in the pathophysiology of primary rhegmatogenous retinal detachment (RRD) …

Proliferative vitreoretinopathy (PVR) is the main cause of retinal detachment surgery failure.
The epithelial-mesenchymal transition (EMT) induced by transforming growth factor (TGF …

Background Increasing evidence indicates that immune response underlies the pathology of
type 2 diabetes (T2D). Nevertheless, the specific inflammatory regulators involved in this …

Virus-like particles (VLP) are a promising tool for intracellular gene delivery, yet their
potential in ocular gene therapy remains underexplored. In this study, we bridged this …

Clinical relevance Proliferative vitreoretinopathy (PVR) is still the leading cause of surgical
failure after rhegmatogenous retinal detachment (RRD) repair. The factors that can predict …

Proliferative vitreoretinopathy (PVR), an inflammatory and fibrotic blinding disease, is still a
therapeutic challenge. Retinal pigment epithelial (RPE) cells dislodged in the vitreous play a …