Use of metal-based contrast agents for in vivo MR and CT imaging of phagocytic cells in neurological pathologies
M Wiart, C Tavakoli, V Hubert, I Hristovska… - Journal of Neuroscience …, 2023 - Elsevier
The activation of phagocytic cells is a hallmark of many neurological diseases. Imaging them
in their 3-dimensional cerebral environment over time is crucial to better understand their …
in their 3-dimensional cerebral environment over time is crucial to better understand their …
Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues
A Maes, C Pestiaux, A Marino, T Balcaen… - Nature …, 2022 - nature.com
Biological tissues comprise a spatially complex structure, composition and organization at
the microscale, named the microstructure. Given the close structure-function relationships in …
the microscale, named the microstructure. Given the close structure-function relationships in …
From mouse to man and back: closing the correlation gap between imaging and histopathology for lung diseases
B Tielemans, K Dekoster, SE Verleden, S Sawall… - Diagnostics, 2020 - mdpi.com
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …
X-ray phase tomography with near-field speckles for three-dimensional virtual histology
High-contrast, high-resolution imaging of biomedical specimens is indispensable for
studying organ function and pathologies. Conventional histology, the gold standard for soft …
studying organ function and pathologies. Conventional histology, the gold standard for soft …
[HTML][HTML] X-ray micro-computed tomography for nondestructive three-dimensional (3D) X-ray histology
OL Katsamenis, M Olding, JA Warner… - The American journal of …, 2019 - Elsevier
Historically, micro-computed tomography (μCT) has been considered unsuitable for
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …
[HTML][HTML] Virtual histology of an entire mouse brain from formalin fixation to paraffin embedding. Part 1: Data acquisition, anatomical feature segmentation, tracking …
Background: Micrometer-resolution neuroimaging with gold-standard conventional histology
requires tissue fixation and embedding. The exchange of solvents for the creation of …
requires tissue fixation and embedding. The exchange of solvents for the creation of …
Multiscale X-ray phase-contrast tomography: from breast CT to micro-CT for virtual histology
Phase-contrast imaging techniques address the issue of poor soft-tissue contrast
encountered in traditional X-ray imaging. This can be accomplished with the propagation …
encountered in traditional X-ray imaging. This can be accomplished with the propagation …
[HTML][HTML] 3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis
J Frost, B Schmitzer, M Töpperwien, M Eckermann… - Neuroscience, 2023 - Elsevier
We investigate structural properties of neurons in the granular layer of human cerebellum
with respect to their involvement in multiple sclerosis (MS). To this end we analyze data …
with respect to their involvement in multiple sclerosis (MS). To this end we analyze data …
Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis
Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent
bidimensionality limits histological procedures' effectiveness in identifying these changes …
bidimensionality limits histological procedures' effectiveness in identifying these changes …
Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography–the next dimension of diagnosis
Background The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which
still has one of the lowest survival rates, requires novel imaging tools to improve early …
still has one of the lowest survival rates, requires novel imaging tools to improve early …