Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Background Sorafenib resistance is a key impediment to successful treatment of patients
with advanced hepatocellular carcinoma (HCC) and recent studies have reported reversal of …

Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from
apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a …

Intrinsic and acquired anti-HER2 resistance remains a major hurdle for treating HER2-
positive breast cancer. Using genome-wide CRISPR/Cas9 screening in vitro and in vivo, we …

Ferroptosis is a recently discovered form of regulated cell death that is morphologically,
genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use …

Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Photodynamic Therapy (PDT) holds a great promise for cancer patients, however, due to the
hypoxic characteristics of most solid tumors and the limited penetration depth of light in …