Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

An understanding of the process by which tumor cells destroy the basement membrane of
the surface epithelium, invade, and metastasize is essential to the development of novel …

Neoplastic cells within individual carcinomas often exhibit considerable phenotypic
heterogeneity in their epithelial versus mesenchymal-like cell states. Because carcinoma …

Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor …

Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous
epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor …

Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein
consists of the heterotrimeric assembly of three subunits–α3, β3, and γ2–and its …

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent
roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

The lethal consequences of prostate cancer are related to its metastasis to other organ sites.
Epithelial-to-mesenchymal transition (EMT) has received considerable attention as a …

An important clinical challenge in prostate cancer therapy is the inevitable transition from
androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the …