Human endocannabinoid systems modulate multiple physiological processes mainly
through the activation of cannabinoid receptors CB1 and CB2. Their high sequence …

Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a
G protein-coupled receptor that regulates a number of therapeutically relevant physiological …

Homologation is a concept introduced by Gerhard in 1853 to describe a homologous series
in organic chemistry. Since then, the concept has been adapted and used in medicinal …

To provide a comprehensive framework of the current information on the potency and
efficacy of interaction between phyto-and synthetic cannabinoids and their respective …

Introduction: An escalating number of fatalities resulting from accidental opioid overdoses
typically attributed to respiratory depression continue to define the opioid epidemic. Opioid …

Arachidonoylglycerol (2-AG) is the most potent and abundant endocannabinoid that acts as
a full agonist at the cannabinoid 1 (CB1) and 2 (CB2) receptors. It serves as a substrate for …

Substoichiometric iron mediates the thioetherification of unactivated aliphatic C–H bonds
directed by resident silylperoxides. Upon exposure to a catalytic amount of iron (II) triflate …

Introduction: Cannabis acceptance and use continues to rise despite the gaps in knowledge
regarding the mechanisms of cannabinoids and the endocannabinoid system in many …

2-Arachidonoyl glycerol (2-AG) is the principal endogenously produced ligand for the
cannabinoid CB1 and CB2 receptors (CBRs). The lack of potent and efficacious 2-AG …

In earlier work, we explored the SAR for the C3 side chain pharmacophore in the
hexahydrocannabinol template represented by the drug nabilone, which resulted in the …