Endotheliopathy in acute COVID-19 and long COVID

AG Vassiliou, CS Vrettou, C Keskinidou… - International Journal of …, 2023 - mdpi.com
The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

aMMP-8 oral fluid PoC test in relation to oral and systemic diseases

T Sorsa, SO Nwhator, D Sakellari, A Grigoriadis… - Frontiers in oral …, 2022 - frontiersin.org
The manuscript uses the previously published literature and highlights the benefits of active-
matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as …

Matrix metalloproteinases on severe COVID-19 lung disease pathogenesis: cooperative actions of MMP-8/MMP-2 axis on immune response through HLA-G shedding …

PV da Silva-Neto, VB do Valle, CA Fuzo… - Biomolecules, 2022 - mdpi.com
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung
failure is the most severe complication. While the molecular basis of SARS-CoV-2 …

Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly

CNO Santos, LS Magalhães, ABL Fonseca… - Scientific Reports, 2023 - nature.com
Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV)
infection and the underline mechanisms involved in its occurrence are yet not fully …

Age-related changes in plasma biomarkers and their association with mortality in COVID-19

EHA Michels, B Appelman… - European …, 2023 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …

Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants

TG Paranga, M Pavel-Tanasa… - Frontiers in …, 2023 - frontiersin.org
C-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers
during the ongoing COVID-19 pandemics caused by severe acute respiratory syndrome …

[HTML][HTML] Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections

AH de Nooijer, P Pickkers, MG Netea, M Kox - Journal of Critical Care, 2023 - Elsevier
Mortality in acute infections is mostly associated with sepsis, defined as 'life-threatening
organ dysfunction caused by a dysregulated host response to infection'. It remains …

Active Matrix Metalloproteinase-8 (aMMP-8) Versus Total MMP-8 in Periodontal and Peri-Implant Disease Point-of-Care Diagnostics

IT Räisänen, NRAS Aji, D Sakellari, A Grigoriadis… - Biomedicines, 2023 - mdpi.com
Active matrix metalloproteinase-8 (aMMP-8) is a promising biomarker candidate for the
modern periodontal and peri-implant disease diagnostics utilizing the chairside/point-of-care …

Involvement of matrix metalloproteinases in COVID-19: molecular targets, mechanisms, and insights for therapeutic interventions

R Salomão, V Assis, IV de Sousa Neto, B Petriz… - Biology, 2023 - mdpi.com
Simple Summary The costs worldwide of the coronavirus disease 2019 (COVID-19) have
been tremendous. With millions of deaths in different countries, understanding biomarkers is …

[HTML][HTML] Performance of host-response biomarkers to risk-stratify children with pneumonia in Bhutan

S Jullien, M Richard-Greenblatt, M Ngai, T Lhadon… - Journal of Infection, 2022 - Elsevier
Pneumonia is the leading cause of post-neonatal death amongst children under five years of
age; however, there is no simple triage tool to identify children at risk of progressing to …