Plant metabolism is perturbed by various abiotic stresses. As such the metabolic network of
plants must be reconfigured under stress conditions in order to allow both the maintenance …

Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Metabolomics is an emerging field of postgenomic biology concerned with comprehensive
analysis of small molecules in biological systems. However, difficulties associated with the …

Biological systems are increasingly being studied in a holistic manner, using omics
approaches, to provide quantitative and qualitative descriptions of the diverse collection of …

The metabolome is the set of small molecular mass compounds found in biological media,
and metabolomics, which refers to as the analysis of metabolome in a given biological …

Capillary zone electrophoresis-mass spectrometry (CE-MS) is a mature analytical tool for the
efficient profiling of (highly) polar and ionizable compounds. However, the use of CE-MS in …

Highlights•CE–MS is an attractive analytical tool for analyzing the polar ionogenic
metabolome.•A novel sheathless interface for CE–MS allows highly sensitive metabolic …

A growing number of software tools have been developed for metabolomics data processing
and analysis. Many new tools are contributed by metabolomics practitioners who have …

Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing
deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related …

AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal
damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system …