Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …
aroused great interest in medicinal chemists for the development of new drugs or drug …
CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery
A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
Research progress of indole compounds with potential antidiabetic activity
Y Zhu, J Zhao, L Luo, Y Gao, H Bao, P Li… - European Journal of …, 2021 - Elsevier
New types of antidiabetic agents are continually needed with diabetes becoming the
epidemic in the world. Indole alkaloids play an important role in natural products owing to …
epidemic in the world. Indole alkaloids play an important role in natural products owing to …
A review on synthesis, mechanism of action, and structure-activity relationships of 1, 2, 3-triazole-based α-glucosidase inhibitors as promising anti-diabetic agents
Abstract α-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and
located in the small intestine brush border. Inhibition of this enzyme delay the release of …
located in the small intestine brush border. Inhibition of this enzyme delay the release of …
Design and synthesis of novel quinazolinone-1, 2, 3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study
M Saeedi, M Mohammadi-Khanaposhtani… - Bioorganic …, 2019 - Elsevier
A novel series of quinazolinone-1, 2, 3-triazole hybrids 10a-p were designed, synthesized,
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase …
The aim of the present study is to design and synthesis of new pyrazole-triazolopyrimidine
hybrids as potent α-glucosidase inhibitors. The target compounds 4a-n were synthesized by …
hybrids as potent α-glucosidase inhibitors. The target compounds 4a-n were synthesized by …
Synthesis of 1H-1, 2, 3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies
Inhibition of α-glucosidase is an effective strategy for controlling the post-prandial
hyperglycemia in diabetic patients. For the identification of new inhibitors of this enzyme, a …
hyperglycemia in diabetic patients. For the identification of new inhibitors of this enzyme, a …