Gut microbiota and bone metabolism
L Lu, X Chen, Y Liu, X Yu - The FASEB Journal, 2021 - Wiley Online Library
Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …
The roles of epigenetics regulation in bone metabolism and osteoporosis
F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4
X Zhang, Z Huang, Z Xie, Y Chen, Z Zheng… - Free Radical Biology …, 2020 - Elsevier
Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …
[HTML][HTML] Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice
Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …
is tightly coordinated during bone development. However, the molecular regulators of …
Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage–dependent miR-150-FNDC5/pyroptosis axis
Recent evidence suggests that physical exercise (EX) promotes skeletal development.
However, the impact of EX on the progression of bone loss and deterioration of mechanical …
However, the impact of EX on the progression of bone loss and deterioration of mechanical …
[HTML][HTML] S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis
F Liu, L Yuan, L Li, J Yang, J Liu, Y Chen… - Pharmacological …, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …
[HTML][HTML] Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair
Z Cheng, R Kishore - Redox biology, 2020 - Elsevier
Diabetes is one of the most prevalent metabolic disorders and is estimated to affect 400
million of 4.4% of population worldwide in the next 20 year. In diabetes, risk to develop …
million of 4.4% of population worldwide in the next 20 year. In diabetes, risk to develop …
[HTML][HTML] Probiotics stimulate bone formation in obese mice via histone methylations
Rationale: Manipulation of the gut microbiome can prevent pathologic bone loss. However,
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …
Reactive sulfur and selenium species in the regulation of bone homeostasis
AK Gilbert, TD Newton, MH Hettiaratchi… - Free radical biology and …, 2022 - Elsevier
Reactive oxygen species (ROS) are important modulators of physiological signaling and
play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and …
play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and …
Mechanisms of autophagy and mitophagy in skeletal development, diseases and therapeutics
J Behera, J Ison, A Tyagi, G Mbalaviele, N Tyagi - Life Sciences, 2022 - Elsevier
Autophagy is a highly evolutionarily conserved process in the eukaryotic cellular system by
which dysfunctional organelles are selectively degraded through a series of processes of …
which dysfunctional organelles are selectively degraded through a series of processes of …