Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …

Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …

Recent evidence suggests that physical exercise (EX) promotes skeletal development.
However, the impact of EX on the progression of bone loss and deterioration of mechanical …

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …

Diabetes is one of the most prevalent metabolic disorders and is estimated to affect 400
million of 4.4% of population worldwide in the next 20 year. In diabetes, risk to develop …

Rationale: Manipulation of the gut microbiome can prevent pathologic bone loss. However,
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …

Reactive oxygen species (ROS) are important modulators of physiological signaling and
play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and …

Autophagy is a highly evolutionarily conserved process in the eukaryotic cellular system by
which dysfunctional organelles are selectively degraded through a series of processes of …