Brain-derived neurotrophic factor: Regulation, effects, and potential clinical relevance

EE Benarroch - Neurology, 2015 - AAN Enterprises
Brain-derived neurotrophic factor (BDNF) is the most ubiquitous and intensively studied
member of the family of neurotrophins in the CNS. The transcriptional regulation of BDNF is …

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

LR Goldberg, TJ Gould - European Journal of Neuroscience, 2019 - Wiley Online Library
Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …

Microstructural white matter biomarkers of symptom severity and therapy outcome in catatonia: Rationale, study design and preliminary clinical data of the whiteCAT …

D Hirjak, GA Brandt, R Peretzke, S Fritze… - Schizophrenia …, 2024 - Elsevier
The number of magnetic resonance imaging (MRI) studies on neuronal correlates of
catatonia has dramatically increased in the last 10 years, but conclusive findings on white …

16p11. 2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

M Sundberg, H Pinson, RS Smith, KD Winden… - Nature …, 2021 - nature.com
Reciprocal copy number variations (CNVs) of 16p11. 2 are associated with a wide spectrum
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …

The role of irisin in Alzheimer's disease

OY Kim, J Song - Journal of clinical medicine, 2018 - mdpi.com
Alzheimer's disease (AD) is characterized by progressive memory dysfunction, oxidative
stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the …

Lateral hypothalamic control of the ventral tegmental area: reward evaluation and the driving of motivated behavior

SM Tyree, L de Lecea - Frontiers in systems neuroscience, 2017 - frontiersin.org
The lateral hypothalamus (LH) plays an important role in many motivated behaviors, sleep-
wake states, food intake, drug-seeking, energy balance, etc. It is also home to a …

[HTML][HTML] Multigenerational epigenetic inheritance: One step forward, two generations back

JJ Tuscher, JJ Day - Neurobiology of Disease, 2019 - Elsevier
Modifications to DNA and histone proteins serve a critical regulatory role in the developing
and adult brain, and over a decade of research has established the importance of these …

Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM

X Lang, N Zhao, Q He, X Li, X Li, C Sun, X Zhang - Brain Research Bulletin, 2020 - Elsevier
Although previous studies showed that exercise can improve cognitive dysfunction in type 2
diabetes (T2DM), the underlying mechanism remains unclear. Sirtuin 1 (SIRT1) has been …

Effects of the FNDC5/Irisin on elderly dementia and cognitive impairment

J Peng, J Wu - Frontiers in aging neuroscience, 2022 - frontiersin.org
Population aging is an inevitable problem nowadays, and the elderly are going through a lot
of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating …

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

DW Greening, M Notaras, M Chen, R Xu, JD Smith… - Molecular …, 2021 - nature.com
Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and
can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived …