Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Collagen is the most widely distributed class of proteins in the human body. The use of
collagen-based biomaterials in the field of tissue engineering applications has been …

The fabrication of functional tissue or organs substitutes has always been the pursuit of
goals in the field of tissue engineering. But even biocompatible tissue-engineered scaffolds …

Polyphenols are micronutrients obtained from diet that have been suggested to play an
important role in health. The health benefits of polyphenols and their protective effects in …

Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of
heart valves, arteries and myocardium by creating 'living'tissue replacements outside (in …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

Abstract 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG) is a polyphenolic compound highly
enriched in a number of medicinal herbals. Several in vitro and a handful of in vivo studies …

Collagen and elastin represent the two most predominant proteins in the body and are
responsible for modulating important biological and mechanical properties. Thus, the focus …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Heart valve tissue engineering could be a possible solution for the limitations of mechanical
and biological prostheses, which are commonly used for heart valve replacement. In tissue …