The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy

ALM Parsons, EMV Bucknor, E Castroflorio, TR Soares… - Antioxidants, 2022 - mdpi.com
One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

A comprehensive review on anti-inflammatory response of flavonoids in experimentally-induced epileptic seizures

SS Rabidas, C Prakash, J Tyagi, J Suryavanshi… - Brain Sciences, 2023 - mdpi.com
Flavonoids, a group of natural compounds with phenolic structure, are becoming popular as
alternative medicines obtained from plants. These compounds are reported to have various …

Neuroinflammation catching nanobubbles for microglia-neuron unit modulation against epilepsy

X Wang, Y Liu, M Li, Y Ju, J Tang, T Chen, X Lin, N Gu… - Biomaterials, 2023 - Elsevier
Epilepsy is a common neurological disease caused by synchronous firing of hyperexcitable
neurons. Currently, patients with epilepsy are typically treated with antiseizure medicines …

Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy

EA Filimonova, AA Pashkov, GI Moysak… - Frontiers in …, 2023 - frontiersin.org
Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a
significant burden on the health care system worldwide. Approximately one-third of patients …

High mobility group box protein (HMGB1): A potential therapeutic target for diabetic encephalopathy

UK Dash, D Mazumdar, S Singh - Molecular Neurobiology, 2024 - Springer
HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein
superfamilies that make up the HMG (high mobility group) protein group. HMGB1 is involved …

Sleep disruption worsens seizures: neuroinflammation as a potential mechanistic link

H Bonilla-Jaime, H Zeleke, A Rojas… - International journal of …, 2021 - mdpi.com
Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness,
are common in people diagnosed with epilepsy. These disturbances can be attributed to …

Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis

MF Hammer, E Bahramnejad, JC Watkins… - Clinical …, 2024 - portlandpress.com
Blockade of Angiotensin type 1 receptor (AT1R) has potential therapeutic utility in the
treatment of numerous detrimental consequences of epileptogenesis, including oxidative …

Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics

BG de Liyis, SG Tandy, JF Endira, KA Putri… - The Egyptian Journal of …, 2022 - Springer
Epilepsy, a neurological illness, is characterized by recurrent uncontrolled seizures. There
are many treatments of options that can be used as the therapy of epilepsy. However, anti …

[HTML][HTML] Ligand-receptor interactions: A key to understanding microglia and astrocyte roles in epilepsy

P Thergarajan, TJ O'Brien, NC Jones, I Ali - Epilepsy & Behavior, 2025 - Elsevier
Epilepsy continues to pose significant social and economic challenges on a global scale.
Existing therapeutic approaches predominantly revolve around neurocentric mechanisms …

Circulating HMGB1 in acute ischemic stroke and its association with post-stroke cognitive impairment

Z Liu, W Yang, J Chen, Q Wang - PeerJ, 2024 - peerj.com
Background Ischemic stroke frequently leads to a condition known as post-stroke cognitive
impairment (PSCI). Timely recognition of individuals susceptible to developing PSCI could …