The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …

The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is
nothing less than a death sentence, with few treatment options for palliation or prolonging …

An open question in aggressive cancers such as melanoma is how malignant cells can shift
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …

Glioblastoma (GBM) is a lethal form of primary brain tumor in human adults. The impact of
tumor-intrinsic alterations is not exclusively confined to cancer cells but can also be …

Purpose: Neuronal activity in the brain has been reported to promote the malignant
progression of glioma cells via nonsynaptic paracrine and electrical synaptic integration …