Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …

Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes,
plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis …

Chondrogenesis is a multistep process that is essential for endochondral bone formation.
Previous results have indicated a role for β-catenin and Wnt signaling in this pathway. Here …

The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic
agents. Several studies have been performed, new studies are emerging out and yet …

Endochondral bone development is a complex process in which undifferentiated
mesenchymal cells differentiate into chondrocytes, which then undergo well-ordered and …

Chondrocyte differentiation is a multi‐step process characterized by successive changes in
cell morphology and gene expression. In addition to tight regulation by numerous soluble …

Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

Background—Transplantation of endothelial progenitor cells (EPCs) improves
neovascularization after ischemia, but patients with coronary artery disease (CAD) or …

FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a
negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones …

Runx2, required for bone formation, is ectopically expressed in breast cancer cells. To
address the mechanism by which Runx2 contributes to the osteolytic disease induced by …