Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …

The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three malignancies—
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's …

Viral latency can be considered a metastable, nonproductive infection state that is capable
of subsequent reactivation to repeat the infection cycle. Viral latent infections have …

The COVID-19 pandemic reminds us that in spite of the scientific progress in the past
century, there is a lack of general antiviral strategies. In analogy to broad-spectrum …

The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for
ADP-ribosylation, a reversible post-translational modification involved in many cellular …

The literature review presented here details recent research involving members of the poly
(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of …

Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To
this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is …

The induction of DNA damage together with the interference with DNA repair represents a
promising strategy in cancer treatment. Here we show that the PARP-1/2/3 inhibitor …