An analysis of 156 published clinical candidates from the Journal of Medicinal Chemistry
between 2018 and 2021 was conducted to identify lead generation strategies most …

Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

Enhancing α7 nAChR function serves as a therapeutic strategy for cognitive disorders. Here,
we report the synthesis and evaluation of 2-arylamino-thiazole-5-carboxylic acid amide …

Catalytic enantioselective domino alkenylation-alkynylation of alkenes: stereoselective
synthesis of 5–7 membered azacycles an Page 1 •COMMUNICATIONS• June 2023 Vol.66 …

With continued smoking of tobacco products and expanded use of nicotine delivery devices
worldwide, understanding the impact of smoking and vaping on respiratory health remains a …

Abstract N-methyl-D-aspartate-receptor (NMDAR) hypofunction contributes to cognitive
impairments in neuropsychiatric disorders such as schizophrenia. Reduced NMDAR …

Enhancing neuronal α7 nicotinic acetylcholine receptor (α7 nAChR) function can alleviate
cognitive deficits. Here, we report the design, synthesis, and evaluation of N-(4 …

Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to
the importance of pyrrole structure in drug design and development, herein, we tried to …