Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American Heart …

MH Criqui, K Matsushita, V Aboyans, CN Hess… - Circulation, 2021 - Am Heart Assoc
Lower extremity peripheral artery disease (PAD) affects> 230 million adults worldwide and is
associated with increased risk of various adverse clinical outcomes (other cardiovascular …

Epidemiology of peripheral artery disease and polyvascular disease

AW Aday, K Matsushita - Circulation research, 2021 - Am Heart Assoc
Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized
as an important cause of cardiovascular morbidity and mortality that affects> 230 million …

Update on the pathophysiology and medical treatment of peripheral artery disease

J Golledge - Nature reviews cardiology, 2022 - nature.com
Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic …

L Mazzolai, G Teixido-Tura, S Lanzi, V Boc… - European heart …, 2024 - academic.oup.com
• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Advances in revascularization for peripheral artery disease: revascularization in PAD

JA Beckman, PA Schneider, MS Conte - Circulation research, 2021 - Am Heart Assoc
Effective revascularization of the patient with peripheral artery disease is about more than
the procedure. The approach to the patient with symptom-limiting intermittent claudication or …

Arginine and endothelial function

J Gambardella, W Khondkar, MB Morelli, X Wang… - Biomedicines, 2020 - mdpi.com
Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Reducing nontraumatic lower-extremity amputations by 20% by 2030: time to get to our feet: a policy statement from the American Heart Association

MA Creager, K Matsushita, S Arya, JA Beckman… - Circulation, 2021 - Am Heart Assoc
Nontraumatic lower-extremity amputation is a devastating complication of peripheral artery
disease (PAD) with a high mortality and medical expenditure. There are≈ 150 000 …

Leveraging machine learning and artificial intelligence to improve peripheral artery disease detection, treatment, and outcomes

AM Flores, F Demsas, NJ Leeper, EG Ross - Circulation research, 2021 - Am Heart Assoc
Peripheral artery disease is an atherosclerotic disorder which, when present, portends poor
patient outcomes. Low diagnosis rates perpetuate poor management, leading to limb loss …

Microvascular disease increases amputation in patients with peripheral artery disease

A Behroozian, JA Beckman - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
It is estimated that> 2 million patients are living with an amputation in the United States.
Peripheral artery disease (PAD) and diabetes mellitus account for the majority of …

Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

T Deuse, G Tediashvili, X Hu… - Proceedings of the …, 2021 - National Acad Sciences
The emerging field of regenerative cell therapy is still limited by the few cell types that can
reliably be differentiated from pluripotent stem cells and by the immune hurdle of …