RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …
genomes that enable the infection to persist despite challenges presented by host cells …
A review of potential suggested drugs for coronavirus disease (COVID-19) treatment
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high
prevalence and easy transmission, which is expanding globally with no conventional …
prevalence and easy transmission, which is expanding globally with no conventional …
Oral antiviral treatments for COVID-19: opportunities and challenges
L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …
and prevent disease progression to a more severe form. However, the timing of antiviral …
Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies
Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …
insatiable need to replicate while evading the host immune system. These similarities …
Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing
AP Salam, A Duvignaud, M Jaspard… - PLoS Neglected …, 2022 - journals.plos.org
Ribavirin is currently the standard of care for treating Lassa fever. However, the human
clinical trial data supporting its use suffer from several serious flaws that render the results …
clinical trial data supporting its use suffer from several serious flaws that render the results …
Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection
T Tipih, K Meade-White, D Rao, T Bushmaker, M Lewis… - Antiviral Research, 2023 - Elsevier
Crimean-Congo hemorrhagic fever virus (CCHFV) causes Crimean-Congo hemorrhagic
fever (CCHF) in humans with high morbidity and mortality. Currently, there is neither an …
fever (CCHF) in humans with high morbidity and mortality. Currently, there is neither an …
Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein
HM Williams, SR Thorkelsson, D Vogel… - Nucleic acids …, 2023 - academic.oup.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a phenuivirus that has
rapidly become endemic in several East Asian countries. The large (L) protein of SFTSV …
rapidly become endemic in several East Asian countries. The large (L) protein of SFTSV …
SARS-CoV, MERS-CoV and SARS-CoV-2 infections in pregnancy and fetal development
GA de Souza Silva, SP da Silva, MAS da Costa… - Journal of gynecology …, 2020 - Elsevier
Abstract Recently, in China, in 2019, a new type of disease has arisen caused by a new
strain of coronavirus, the SARS-CoV-2 virus, considered extremely worrying due to its high …
strain of coronavirus, the SARS-CoV-2 virus, considered extremely worrying due to its high …
SARS-CoV-2: Current trends in emerging variants, pathogenesis, immune responses, potential therapeutic, and vaccine development strategies
A Salimi-Jeda, S Abbassi, A Mousavizadeh… - International …, 2021 - Elsevier
More than a year after the SARS-CoV-2 pandemic, the Coronavirus disease 19 (COVID-19)
is still a major global challenge for scientists to understand the different dimensions of …
is still a major global challenge for scientists to understand the different dimensions of …