[HTML][HTML] Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy

S Motyka, K Jafernik, H Ekiert, J Sharifi-Rad… - Biomedicine & …, 2023 - Elsevier
The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …

Chemistry and biology of podophyllotoxins: an update

M Hao, H Xu - Chemistry–A European Journal, 2024 - Wiley Online Library
Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of
Podophyllum. It consists of five rings with four chiral centers, one trans‐lactone and one aryl …

Functionalized graphene oxide based nanocarrier for enhanced cytotoxicity of Juniperus squamata root essential oil against breast cancer cells

A Rana, M Matiyani, C Tewari, PB Negi… - Journal of Drug Delivery …, 2022 - Elsevier
Here, we report the efficient loading of Juniperus squamata root essential oil (JSEO) on
polyvinylpyrrolidone (PVP) functionalized graphene oxide (GO-PVP) and investigated …

Juniperus sabina L. as a Source of Podophyllotoxins: Extraction Optimization and Anticholinesterase Activities

S Xu, X Li, S Liu, P Tian, D Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Juniperus sabina L.(J. sabina) has been an important plant in traditional medicine since
ancient times. Its needles are rich in podophyllotoxin, a precursor compound to anti-tumor …

Polycarbonate-based copolymer micelles as biodegradable carriers of anticancer podophyllotoxin or juniper extracts

RG Kalinova, IV Dimitrov, DI Ivanova, YE Ilieva… - Journal of Functional …, 2024 - mdpi.com
Podophyllotoxin (PPT) is used in the industrial production of efficient anticancer, antiviral
and other drugs. Sinopodophyllum hexandrum or Podophyllum peltatum are natural sources …

Juniperus sabina L. essential oils and podophyllotoxin seasonal and interpopulation dynamics

VD Zheljazkov, I Semerdjieva, L De Martino… - Industrial Crops and …, 2024 - Elsevier
Juniperus sabina L., commonly known as Savin, is an evergreen shrub from Cupressaceae
family, grown as an ornamental all over the world. J. sabina contains two valuable …

[HTML][HTML] Beyond Essential Oils: Diterpenes, Lignans, and Biflavonoids from Juniperus communis L. as a Source of Multi-Target Lead Compounds

AA Jojić, S Liga, D Uţu, G Ruse, L Suciu, A Motoc… - Plants, 2024 - mdpi.com
Common Juniper (Juniperus communis L.) is a gymnosperm that stands out through its
fleshy, spherical female cones, often termed simply “berries”. The cone berries and various …

Plant-inspired adhesive and injectable natural hydrogels: In vitro and in vivo studies

CD Bohórquez-Moreno, KE Öksüz, E Dinçer… - Biotechnology …, 2023 - Springer
The development of alternative therapeutic treatments based on the use of medicinal and
aromatic plants, such as Juniper communis L., has aroused interest in the medical field to …

Anticancer podophyllotoxin recovery from juniper leaves at atmospheric and high pressure using eco-friendly solvents

D Ivanova, P Nedialkov, A Tashev… - Plants, 2023 - mdpi.com
Podophyllotoxin (PPT) is a precursor for the synthesis of drugs against cancer and other
diseases. The present sources of PPT (Sinopodophyllum hexandrum and Podophyllum …

Green Ultrasound-Assisted Extraction of Podophyllotoxin from Juniperus scopulorum Needles

C Verret, A Rakotondramavo, S Renouard - Applied Sciences, 2023 - mdpi.com
Background—Podophyllotoxin, a polyphenolic compound with major applications in cancer
treatment, is in short supply, as its source is now an endangered plant species. It is therefore …