Current knowledge of hypertriglyceridemic pancreatitis

P Valdivielso, A Ramírez-Bueno, N Ewald - European journal of internal …, 2014 - Elsevier
Severe hypertriglyceridemia (HTG) is a well established and the most common cause of
acute pancreatitis (AP) after alcohol and gall stone disease. It is alleged to account for up to …

Lipoprotein lipase: structure, function, regulation, and role in disease

JR Mead, SA Irvine, DP Ramji - Journal of molecular medicine, 2002 - Springer
Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of
circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified …

Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis

IJ Goldberg - Journal of lipid research, 1996 - Elsevier
Although it has been known for over 50 years that lipoprotein lipase (LPL) hydrolyzes
triglyceride in chylomicrons, during the past half decade there has been a reinterest in the …

The importance of lipoprotein lipase regulation in atherosclerosis

A Kumari, KK Kristensen, M Ploug, AML Winther - Biomedicines, 2021 - mdpi.com
Lipoprotein lipase (LPL) plays a major role in the lipid homeostasis mainly by mediating the
intravascular lipolysis of triglyceride rich lipoproteins. Impaired LPL activity leads to the …

Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

R Fraser, BR Dobbs, GWT Rogers - Hepatology, 1995 - journals.lww.com
The liver sieve, formed by the fenestrated hepatic sinusoidal endothelium, is a dynamic
biofilter separating the hepatic blood from the plasma within the space of Disse. It filters …

Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases

WS Harris, G Lu, GS Rambjør, AI Wõlen… - The American journal of …, 1997 - Elsevier
The aim of these studies was to explore the possibility that enhanced triacylglycerol
clearance may contribute to the hypotriacylglycerolemic effect of n-3 fatty acids in humans …

Lipoprotein lipase and the disposition of dietary fatty acids

BA Fielding, KN Frayn - British Journal of Nutrition, 1998 - cambridge.org
Lipoprotein lipase (EC 3.1. 1.34; LPL) is a key enzyme regulating the disposal of lipid fuels
in the body. It is expressed in a number of peripheral tissues including adipose tissue …

[PDF][PDF] Lipoprotein lipase: physiology, biochemistry, and molecular biology

IJ Goldberg, M Merkel - Front Biosci, 2001 - article.imrpress.com
[Frontiers in Bioscience 6, d388-405, March 1, 2001] 388 LIPOPROTEIN LIPASE:
PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR BIOLOGY Ira Page 1 [Frontiers in …

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

MS Nielsen, C Jacobsen, G Olivecrona… - Journal of Biological …, 1999 - ASBMB
Lipoprotein lipase and the receptor-associated protein (RAP) bind to overlapping sites on
the low density lipoprotein receptor-related protein/α 2-macroglobulin receptor (LRP). We …

Structure of dimeric lipoprotein lipase reveals a pore adjacent to the active site

KH Gunn, SB Neher - Nature Communications, 2023 - nature.com
Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free
fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for …