Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

Lipid nanoparticles (LNPs) have become the dominant drug delivery technology in industry,
holding the promise to deliver RNA to up or down‐regulate any protein of interest. LNPs …

Platelet glycoprotein VI (GPVI) is attracting interest as a potential target for the development
of new antiplatelet molecules with a low bleeding risk. GPVI binding to vascular collagen …

Objective—ACT017 is a novel, first in class, therapeutic antibody to platelet GPVI
(glycoprotein VI) with potent and selective antiplatelet effects. This first-in-human …

Besides their role in hemostasis and thrombosis, it has become increasingly clear that
platelets are also involved in many other pathological processes of the vascular system …

Objective: Atherothrombosis occurs upon rupture of an atherosclerotic plaque and leads to
the formation of a mural thrombus. Computational fluid dynamics and numerical models …

Ischemic stroke is among the leading causes of disability and death worldwide. In acute
ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary …

Platelets play a central role in arrest of bleeding. The ability of platelets to engage with
extracellular matrix proteins of the subendothelium has long been recognised as a pivotal …

Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the
main trigger of platelet activation und acute arterial thrombotic occlusion leading to …