Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells
(ILCs). While most previously studied NK cells were derived from the mouse spleen and …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

Asthma is a chronic inflammatory airway disorder whose pathophysiological and
immunological mechanisms are not completely understood. Asthma exacerbations are …

Efficient immune responses against invading pathogens often involve coordination between
cells from both the innate and adaptive immune systems. For multiple decades, it has been …

Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in
killing infected or transformed cells. NK cells mediate their effector functions using non …

The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK
cells and provides another opportunity to study NK cells. Although evidence has suggested …

Natural killer (NK) cells are large granular lymphocytes largely recognized for their
importance in tumour surveillance and the host response to viral infections. However, as the …

Although type 1 innate lymphoid cells (ILC1s) have been originally found as liver-resident
ILCs, their pathophysiological role in the liver remains poorly investigated. Here, we …

Although natural killer (NK) cells were initially named for their spontaneous tumor-killing
capacity, their concept has been greatly expanded with more than 40 years of extensive …