[HTML][HTML] Collaborative efforts driving progress in pediatric acute myeloid leukemia

CM Zwaan, EA Kolb, D Reinhardt… - Journal of clinical …, 2015 - ncbi.nlm.nih.gov
Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid
leukemia (AML) have made enormous progress during the past decades. Because AML is a …

Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel

U Creutzig, MM van Den Heuvel-Eibrink… - Blood, The Journal …, 2012 - ashpublications.org
Despite major improvements in outcome over the past decades, acute myeloid leukemia
(AML) remains a life-threatening malignancy in children, with current survival rates of∼ …

[HTML][HTML] Pediatric acute myeloid leukemia—past, present, and future

D Reinhardt, E Antoniou, K Waack - Journal of clinical medicine, 2022 - mdpi.com
JCM | Free Full-Text | Pediatric Acute Myeloid Leukemia—Past, Present, and Future Next
Article in Journal Sexual Habits and Sexual Dysfunctions in a Sample of Patients with Psychotic …

Predisposition to cancer in children and adolescents

CP Kratz, MC Jongmans, H Cavé… - The lancet child & …, 2021 - thelancet.com
Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy

CW Elgarten, R Aplenc - Current Opinion in Pediatrics, 2020 - journals.lww.com
Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …

[PDF][PDF] An Inv (16)(p13. 3q24. 3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

TA Gruber, AL Gedman, J Zhang, CS Koss, S Marada… - Cancer cell, 2012 - cell.com
To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia
(non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 …

Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes

JDE De Rooij, C Branstetter, J Ma, Y Li, MP Walsh… - Nature …, 2017 - nature.com
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) in
which cells morphologically resemble abnormal megakaryoblasts. While rare in adults …

[HTML][HTML] Transient abnormal myelopoiesis and AML in Down syndrome: an update

N Bhatnagar, L Nizery, O Tunstall, P Vyas… - Current hematologic …, 2016 - Springer
Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …

Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial

BES Gibson, DKH Webb, AJ Howman… - British journal of …, 2011 - Wiley Online Library
Summary The Medical Research Council Acute Myeloid Leukaemia 12 (MRC AML12) trial
(children) addressed the optimal anthracenedione/anthracycline in induction and the …

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

JH Klusmann, U Creutzig… - Blood, The Journal …, 2008 - ashpublications.org
Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient
leukemia (TL). Though TL resolves spontaneously in most patients, early death and …