5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Opioids are widely used as therapeutic agents against moderate to severe acute and
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and
synthetic ligands, represent the largest family of druggable targets in the human genome …

Tannins are a heterogeneous group of high MW, water‐soluble, polyphenolic compounds,
naturally present in cereals, leguminous seeds and, predominantly, in many fruits and …

Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …

Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

Background and Purpose Cannabidiol has been reported to act as an antagonist at
cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid …

Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased
blood–brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) …

Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐
oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables …