Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Recent decades have seen groundbreaking advances in cancer research. Genetically
engineered animal models, mainly in mice, have contributed to a better understanding of the …

Fluorescence imaging is currently being actively developed for surgical guidance; however,
it remains underutilized for diagnostic and endoscopic surveillance of incipient colorectal …

Early and comprehensive endoscopic detection of colonic dysplasia—the most clinically
significant precursor lesion to colorectal adenocarcinoma—provides an opportunity for …

Background In humans and livestock species, genome-wide association studies (GWAS)
have been applied to study the association between variants distributed across the genome …

Traditional laboratory model organisms are indispensable for cancer research and have
provided insight into numerous mechanisms that contribute to cancer development and …

Swine biomedical models have been gaining in popularity over the last decade, particularly
for applications in oncology research. Swine models for cancer research include pigs that …

Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor
incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental …

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis - Cellular and
Molecular Gastroenterology and Hepatology Skip to Main Content Skip to Main Menu …

Introduction The amount of time and money invested into cancer drug research,
development, and clinical trials has continually increased over the past few decades …