Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …

Breast cancer exhibits the highest global incidence among all tumor types. Regardless of
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

Background The E-cadherin gene (CDH1) maps, at chromosome 16q22. 1, a region often
associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is …

Cancer is a disease associated with aging. More than 80% of human cancers are diagnosed
in people aged 55 years or older. Autophagy has recently been demonstrated to be a novel …

Breast cancer is the most common malignancy in women around the world. About one in 12
women in the West develop breast cancer at some point in life. It is estimated that 5%-10 …

Loss of heterozygosity at the long arm of chromosome 16 is one of the most frequent genetic
events in breast cancer. In the search for tumour suppressor genes that are the target of loss …

The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2)
has been reported to be associated with familial breast cancer in families in which mutations …