Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …

Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

Lentiviral vectors are increasingly utilized in cell and gene therapy applications because
they efficiently transduce target cells such as hematopoietic stem cells and T cells. Large …

Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

Lentiviral vectors (LVs) have gained value over recent years as gene carriers in gene
therapy. These viral vectors are safer than what was previously being used for gene transfer …

Introduction: Lentiviruses are a very potent class of viral vectors for which there is presently a
rapidly growing interest for a number of gene therapy. However, their construction …

Lentiviral vectors (LVs) have been increasingly used as a tool for gene and cell therapies
since they can stably integrate the genome in dividing and nondividing cells. LV production …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

Chimeric antigen receptor (CAR) T-cells represent a paradigm shift in cancer
immunotherapy and a new milestone in the history of oncology. In 2017, the Food and Drug …