Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Locoregional recurrence negatively impacts both long‐term survival and quality of life for
several malignancies. For appropriate‐risk patients with an isolated, resectable, local …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …

Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation
and surgery to optimize outcomes for individual patients. No accurate model of RC exists to …

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer
address diagnosis, staging, surgical management, perioperative treatment, management of …

Purpose Total mesorectal excision with fluorouracil-based preoperative chemoradiotherapy
and postoperative chemotherapy is a standard treatment of locally advanced rectal cancer …

Purpose: Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to
neoadjuvant chemotherapy. Experimental Design: dMMR rectal tumors at Memorial Sloan …

Background Treatment of patients with non-metastatic, locally advanced rectal cancer
(LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post …

CRC is the third most commonly diagnosed malignancy and the fourth leading cause of
cancer-related death in the world. With advances in treatment, colorectal cancer is being …