TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

The fallopian tube secretory cell is the cell of origin for the majority of ovarian cancers.
Although it remains unclear what triggers neoplastic transformation of these cells, certain …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

The tumour suppressor p53 is activated following genotoxic stress and regulates the
expression of target genes involved in the DNA damage response (DDR). The discovery that …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …