The urinary tract comprises the renal pelvis, the ureter, the urinary bladder, and the urethra.
The tract acts as a functional unit, first propelling urine from the kidney to the bladder, then …

The structural and functional similarity of the larval zebrafish pronephros to the human
nephron, together with the recent development of easier and more precise techniques to …

How local groundwater induces chronic kidney disease of unknown etiology (CKDu) in Sri
Lanka is still elusive. This study aims to elucidate the impacts of Sri Lanka's local …

Previous studies in developing Xenopus and zebrafish reported that the phosphate
transporter slc20a1a is expressed in pronephric kidneys. The recent identification of …

Although enormous effort has been made to further improve the operative techniques
worldwide, the management of bladder exstrophy (BE) remains one of the most significant …

DNA methylation is an epigenetic mark that plays an important role in defining cancer
phenotypes, with global hypomethylation and focal hypermethylation at CpG islands …

Congenital anomalies of the kidney and urinary tract (CAKUT) represent a broad range of
diseases with differing mechanisms, clinical presentations, and prognoses. With an …

Genital malformations are among the most common human birth defects, and both genetic
and environmental factors can contribute to these malformations. Development of the …

Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior
urethral valves (PUV), a male limited anatomical obstruction of the urethra affecting 1 in …

Polycomb group (PcG) proteins are transcriptional repressors that are important regulators
of cell fate during embryonic development. Among them, Ezh2 is responsible for catalyzing …