A guide to membraneless organelles and their various roles in gene regulation
T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
[HTML][HTML] The molecular language of membraneless organelles
Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …
membrane-bound or membraneless. A large number of membraneless organelles, including …
A day in the life of the spliceosome
One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes
B Kastner, CL Will, H Stark… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …
undergoes numerous structural and compositional rearrangements that lead to the formation …
[HTML][HTML] An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20
large foci that we show are completely coincident with paraspeckles, nuclear domains …
large foci that we show are completely coincident with paraspeckles, nuclear domains …
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …
[HTML][HTML] Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies
W Liu, S Liu, P Li, K Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …
The Cajal body and histone locus body
Z Nizami, S Deryusheva… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been
carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs …
carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs …
Cajal bodies: where form meets function
M Machyna, P Heyn… - Wiley Interdisciplinary …, 2013 - Wiley Online Library
The cell nucleus contains dozens of subcompartments that separate biochemical processes
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …
Nuclear bodies: news insights into structure and function
D Staněk, AH Fox - Current Opinion in Cell Biology, 2017 - Elsevier
Highlights•Cajal bodies have a definitive role in regulating the maturation of
snRNPs.•Numerous nuclear bodies contain scaffolding RNAs, including paraspeckles and …
snRNPs.•Numerous nuclear bodies contain scaffolding RNAs, including paraspeckles and …