Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …

NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20
large foci that we show are completely coincident with paraspeckles, nuclear domains …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …

The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been
carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs …

The cell nucleus contains dozens of subcompartments that separate biochemical processes
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …

Highlights•Cajal bodies have a definitive role in regulating the maturation of
snRNPs.•Numerous nuclear bodies contain scaffolding RNAs, including paraspeckles and …